RNA technologies made headlines in 2021 when the first mRNA-based COVID-19 vaccine was approved in December 2020. However, RNA therapy is not a new technology. RNA modalities have been under development for several decades and by Jan 2020, the U.S Food and Drug Administration (FDA) had approved a total
1. Merck makes big R&D investment with $3.5B Orna deal ORNA Therapeutics recently struck a deal with Merck to collaborate on the advancement of Orna’s Next Generation of RNA Technology. What does ORNA Therapeutics do? In the next revolution in RNA therapeutics, oRNA molecules are engineered as
Given the incredible growth in mRNA vaccines, it is no surprise that companies are trying to improve this technology. mRNA technology came to the forefront in 2020 with the widespread use of mRNA vaccines for protection against the SARS-CoV2 virus. Just like any other technology, mRNA technology has its drawbacks.
Current offerings This article covers the bottlenecks faced by mRNA vaccines such as supply chain requirements and rapid degradation leading to limited-expression and efficacy. This can be addressed efficiently by more stable DNA vaccines thus not requiring cold chain handling and allowing for prolonged-expression which should improve the efficacy and
In this article, we will focus on the basics of RNA, mRNA, and how mRNA vaccines work. Let's begin, shall we? What are RNA and mRNA? DNA (You can refer to our previous article to understand DNA better) is the genetic material of most organisms on Earth. They are the